article · Journal of Molecular Structure

(E)-N'-(4-chlorobenzylidene)-5-methyl-1H-pyrazole-3-carbohydrazide as a potential PI3Kα targeting scaffold, synthesis, X-ray crystallography, DFT, molecular docking, molecular dynamics simulations, and MMGBSA analysis

Issam Ameziane El Hassani
Anouar Ameziane El Hassani
M’hammed Ansar
Abidemi Paul Kappo
Cemile Baydere Demir
Mustafa Alhaji Isa
Necmİ Dege
Abdullah Yahya Abdullah Alzahrani
Khalid Karrouchi

2026University of Maiduguri

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No abstract is available for this record, so no summary has been generated.

Research topics

PI3K/AKT/mTOR signaling in cancer
Synthesis and biological activity
Melanoma and MAPK Pathways

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1016/j.molstruc.2026.145569

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