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article · Oxford Medical Case Reports

Durable clinical and metabolic response to Trastuzumab Deruxtecan in heavily Pretreated male HER2-low metastatic breast cancer: a case report

2025Open accessMohammed V University

Abstract

This case highlights the potential efficacy and tolerability of T-DXd in men and challenges the systematic exclusion of male patients from clinical trials involving HER2-low mBC. We advocate routine HER2-low testing and gender-inclusive trial design.

Research topics

  • Male Breast Health Studies
  • Prostate Cancer Treatment and Research
  • Advanced Breast Cancer Therapies

Sustainable Development Goals

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DOI: 10.1093/omcr/omaf182

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