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article · Life Sciences

Dual regulating of mitochondrial fusion and Timp-3 by leflunomide and diallyl disulfide combination suppresses diethylnitrosamine-induced hepatocellular tumorigenesis in rats

202220 citationsOpen accessKafr el-Sheikh University

Abstract

the treatment with a combination of LF and DADS displayed a more potent effect than the treatment with each drug alone. Our results suggest that the combined use of LF and a naturally occurring DADS can be used as a promising novel combination in managing HCC.

Research topics

  • Redox biology and oxidative stress
  • Mitochondrial Function and Pathology
  • Metal complexes synthesis and properties

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DOI: 10.1016/j.lfs.2022.120369

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