article · Pediatric Research
gov/study/NCT06367881?term=NCT06367881&rank=1 IMPACT: High-dose Alveofact + budesonide lowers NETs, PAD4, and oxidative stress. Plasma NETs strongly correlate with normalized tracheal aspirates NETs. First trial to test surfactant-steroid effects on neutrophil pathways in RDS. Therapy reduces neutrophil-mediated inflammation in preterm neonates. Plasma NETs may serve as a minimally invasive biomarker for RDS monitoring.
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DOI: 10.1038/s41390-026-04824-9
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