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article · Journal of Clinical Laboratory Analysis

DNA testing for sickle cell anemia in Africa: Implementation choices for the Democratic Republic of Congo

20226 citationsOpen accessUniversité de Kinshasa (UNIKIN)

Abstract

The implemented DNA-based test approach overcomes the limitations faced by hemoglobin-based tests, while being more affordable. We propose to implement the RFLP test as a first line diagnostic test after transfusion and as second tiers for newborn screening. However, users should be aware that this test is unable to differentiate HbC from HbS or identify other point mutation of gene deletion of HBB gene.

Research topics

  • Hemoglobinopathies and Related Disorders
  • Iron Metabolism and Disorders
  • Prenatal Screening and Diagnostics

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DOI: 10.1002/jcla.24398

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