article · Tissue and Cell

Distinct impact of splenic denervation and the role of TRPV1 in LIPUS-induced anti-inflammatory milieu in the kidney: Involvement of neurochemicals, Nrf2/HO-1 modulation and change of macrophage phenotype

Omaima Mohammed Abdelwahed
Sarah Ali Abdelhameed Gouda
Mansour A. Alghamdi
Ebtehal Gamal Abdelhady
Laila Ahmed Rashed
Hend Abdalla
Tarek Shoukry
Basma Emad Aboulhoda
Marwa Alkaffas
Nivin Sharawy

2026Open accessCairo University

Abstract

Integrity of the splenic innervation showed significant association with CGRP, noradrenaline, and acetylcholine levels. Both splenic nerve and TRPV1 potentially influence the macrophage phenotypes-related biomarkers and the expression of Nrf2/HO-1 pathway.

Research topics

Ion Channels and Receptors
Gastrointestinal motility and disorders
Genomics, phytochemicals, and oxidative stress

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DOI: 10.1016/j.tice.2026.103376

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