article · Frontiers in Bioscience-Landmark

Diallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ

Reem S. Alruhaimi
Sulaiman Mohammed Alnasser
Mohammed Alotaibi
Mostafa K. Mohammad
Emad H. M. Hassanein
Omnia A. M. Abd El‐Ghafar
Mohammed A. Alzoghaibi
Ayman M. Mahmoud

20243 citationsOpen accessAssiut University

Abstract

DADS is effective against Cd-induced hepatotoxicity and its beneficial effects are linked to suppression of inflammation, OS and apoptosis and upregulation of PPARγ. DADS could be valuable to protect the liver in individuals at risk of Cd exposure, pending further studies to elucidate other underlying mechanism(s).

Research topics

Heavy Metal Exposure and Toxicity
Hibiscus Plant Research Studies

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DOI: 10.31083/j.fbl2910369

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