article · Urology Case Reports
Secondary tumours of the bladder are rare, and the spread of lung cancer to the bladder via the bloodstream is exceptionally unusual. A medical report describes the first documented case of bladder metastasis originating from pulmonary hepatoid adenocarcinoma, a rare form of lung cancer, in a 72-year-old man undergoing cancer treatment. The bladder mass produced no symptoms and was discovered during routine follow-up examinations. Detailed tissue analysis and immunohistochemical staining confirmed that the tumour was a metastasis from the primary lung cancer, while ruling out primary bladder and liver malignancies. Distinguishing secondary bladder tumours from primary urothelial cancers is challenging and relies heavily on comprehensive immunohistochemistry combined with clinical and radiological findings. Early identification of such metastases is critical to inform appropriate multidisciplinary treatment strategies, even though the overall prognosis for these patients remains poor.
Distinguishing whether a bladder tumour is primary or secondary is vital for selecting the correct cancer treatments. Because symptoms may be completely absent, this case alerts oncologists and pathologists to an unexpected metastatic pathway for a rare lung cancer. Precise diagnostic testing ensures patients receive targeted, multidisciplinary management rather than inappropriate local therapies designed only for primary bladder cancers.
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Secondary bladder tumors are rare, and hematogenous bladder metastases from lung cancer are exceptionally uncommon. We report the first documented case of bladder metastasis from pulmonary hepatoid adenocarcinoma (HAC) in a 72-year-old man undergoing treatment for lung cancer. An asymptomatic bladder mass was detected during follow-up. Histopathology and immunohistochemistry confirmed metastatic pulmonary HAC and excluded primary urothelial and hepatic tumors. This case highlights the diagnostic value of comprehensive immunohistochemistry and clinicoradiological correlation in distinguishing secondary bladder tumors. Early recognition is essential to guide appropriate multidisciplinary management, although prognosis remains poor.
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DOI: 10.1016/j.eucr.2026.103598
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