article · Applied Sciences
Researchers fabricated nanofibrous scaffolds by combining an extract from the medicinal plant Inula graveolens with polycaprolactone using an electrospinning process. The mixture was prepared using five per cent plant extract and eight per cent polymer concentration under optimal conditions. Structural, chemical, and physical assessments evaluated the morphology, crystallisation, surface hydrophilicity, and mechanical strength of the resulting fibres. In laboratory assessments on fibroblast cell lines, the composite scaffolds formed uniform nanofibers and were evaluated for their biological response. The testing confirmed that the materials produced no toxic effects on the cells and supported fibroblast proliferation. These findings demonstrate that plant-loaded polycaprolactone nanofibrous meshes offer biocompatible characteristics suitable for potential biomedical uses.
Natural plant extracts offer bioactive properties that can enhance synthetic materials used in healthcare. By integrating medicinal plant compounds into biocompatible polymer fibres, this research highlights a route to produce safe, non-toxic scaffolds that encourage cell growth. Such materials serve as key foundational components for developing advanced biomaterials and supportive structures for cellular repair.
The work points towards potential biomedical applications, particularly where non-toxic scaffolds that support cell proliferation are required. Biomedical product developers and biomaterial manufacturers could utilise these formulations for tissue support technologies. However, the research is at an early laboratory stage, relying on initial synthesis and in vitro cell culture tests, meaning extensive preclinical and clinical validation is still needed before commercial deployment.
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Recently, there has been a growing interest in research on nanofibrous scaffolds developed by electrospinning bioactive plant extracts. In this study, the extract material obtained from the medicinal plant Inula graveolens (L.) was loaded on polycaprolactone (PCL) electrospun polymeric nanofibers. The combined mixture was prepared by 5% of I. graveolens at 8% (PCL) concentration and electrospun under optimal conditions. The chemical analysis, morphology, and crystallization of polymeric nanofibers were carried out by (FT-IR) spectrometer, scanning electron microscopy (SEM), and XRD diffraction. Hydrophilicity was determined by a contact angle experiment. The strength was characterized, and the toxicity of scaffolds on the cell line of fibroblasts was finally investigated. The efficiency of nanofibers to enhance the proliferation of fibroblasts was evaluated in vitro using the optimal I. graveolens/PCL solutions. The results show that I. graveolens/PCL polymeric scaffolds exhibited dispersion in homogeneous nanofibers around 72 ± 963 nm in the ratio 70/30 (V:V), with no toxicity for cells, meaning that they can be used for biomedical applications.
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DOI: 10.3390/app11020828
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