article · RSC Medicinal Chemistry

Development, biological evaluation, and molecular modelling of novel isocytosine and guanidine derivatives as BACE1 inhibitors using a fragment growing strategy

Asmaa M. Atta
Ahmad Abdelwaly
Samia M. Moustafa
Mohamed Saleh Elgawish
Mohamed S. Nafie
Nouran F. Rihan
Mohamed A. Helal
Khaled M. Darwish

20251 citationOpen accessBadr University in Cairo

Abstract

characterization of selected drug-like candidates of the benzimidazole series AMK-IV, namely 16a and 16k, demonstrated their ability to reduce oxidation stress and their safety within brain and liver tissues.

Research topics

Computational Drug Discovery Methods
Cholinesterase and Neurodegenerative Diseases
Drug Transport and Resistance Mechanisms

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DOI: 10.1039/d4md00698d

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