article · Future Medicinal Chemistry

Design, synthesis, in silico, and biological evaluation of novel pyrazolopyrimidinone-based estrogen receptor inhibitors

Sara A. Hesham
Laila Ziko
Khaled A. M. Abouzid
Nahla A. Farag
Rabah A. T. Serya
Mai I. Shahin
Samar Mowafy

2026Ain Shams University

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Abstract

Compounds <b>5a</b> and <b>5b</b> showed remarkable activity toward tumors which have higher estrogen expression.

Research topics

Estrogen and related hormone effects
Synthesis and biological activity
Computational Drug Discovery Methods

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DOI: 10.1080/17568919.2026.2642673

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