article · RSC Advances

Design, nanogel synthesis, anti-proliferative activity and <i>in silico</i> ADMET profile of pyrazoles and pyrimidines as topo-II inhibitors and DNA intercalators

Ahmed K. B. Aljohani
Kurls E. Anwer
Yousef Yakoub Neyaz
Marwa Alsulaimany
Nour E. A. Abd El‐Sattar
Sanadelaslam S. A. El‐Hddad
Nader A. Maghrabi
Alaa M. Alhammad
Mayar N. Aloufi
Luai F. Alahmadi
Turkiah Ali Saeedi
Khaled El‐Adl

20256 citationsOpen accessHeliopolis University

In plain language

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Abstract

Pyrazole derivatives 2 and 3, pyrimidine derivative 4, and their nanogels as drug delivery systems were synthesized, and their cytotoxicity against MCF-7, HCT-116, HepG2 and A549 cells was evaluated.

Research topics

Cancer therapeutics and mechanisms
Synthesis and biological activity
Synthesis and Biological Evaluation

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DOI: 10.1039/d5ra00166h

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