article · European Journal of Medicinal Chemistry

Design and development of 1,5-diarylpyrazole-based multitarget-directed ligands as dual COX-2/HDAC6 inhibitors for Alzheimer's disease therapy: Molecular dynamics and experimental insights

Kamal S. Abdelrahman
Ahmed A. El‐Rashedy
Heba Rady Salem
Ahmed H. A. Abusabaa
Marwa M. Mahfouz
Mostafa M. Elbadawi
Osama M. Soltan
Hiroyuki Konno
Abdelrahman Hamdi
Samar A. El-Adawy
Hend E. Abo Mansour
Eman A. Eissa
Ghada S.A. Ewies
Amany E. Nofal
Amr K. A. Bass

2026Mansoura University

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Research topics

Histone Deacetylase Inhibitors Research
Cholinesterase and Neurodegenerative Diseases
Neurological Disease Mechanisms and Treatments

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DOI: 10.1016/j.ejmech.2026.118738

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