article · Journal of Natural Products
A chemical investigation of <i>Laburnicola nematophila</i>, isolated from cysts of the plant parasitic nematode <i>Heterodera filipjevi</i>, affored three dactylfungin derivatives (<b>1</b>-<b>3</b>) and three tetralone congeners (<b>4</b>-<b>6</b>). Dactylfungin C (<b>1</b>), laburnicolin (<b>4</b>), and laburnicolenone (<b>5</b>) are previously undescribed natural products. Chemical structures of the isolated compounds were determined based on 1D and 2D NMR spectroscopic analyses together with HR-ESI-MS spectrometry and comparison with data reported in the literature. The relative configurations of compounds <b>1</b>, <b>2</b>, and <b>4</b>-<b>6</b> were determined based on their ROESY data and analysis of their coupling constants (<i>J</i> values). The absolute configurations of <b>4</b>-<b>6</b> were determined through the comparison of their measured and calculated TDDFT-ECD spectra. Compounds <b>1</b>-<b>3</b> were active against azole-resistant <i>Aspergillus fumigatus</i>.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1021/acs.jnatprod.4c00623
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
