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article · Communications Medicine

Conserved neutrophil degranulation transcripts in HIV-TB coinfected children across East and Southern Africa

2026Open accessUniversity of Botswana

Abstract

These findings demonstrate a conserved whole-blood transcriptomic signature in pediatric HIV-TB coinfection, while also highlighting regional variation at the isoform level. This supports the use of transcript-level analyses to identify biomarkers and enhance understanding of host responses in diverse African settings.

Research topics

  • Pneumocystis jirovecii pneumonia detection and treatment
  • HIV Research and Treatment
  • HIV-related health complications and treatments

Sustainable Development Goals

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DOI: 10.1038/s43856-025-01284-w

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