Comparison between conventional, grinding, and microwave synthesis of methylpyrazoles as VEGFR-2/HSP90 dual inhibitors

Abstract

AIM: were synthesized as VEGFR-2/HSP90 dual inhibitors. MATERIALS AND METHODS: The eco-friendly synthesis of the desired analogs was performed by conventional, grinding, and microwave-assisted methods. RESULTS: exhibited dual inhibition of VEGFR-2 and HSP90 and prompted MCF-7 cycle arrest at G2/M phase followed by apoptosis stimulation. CONCLUSION: Molecular docking revealed strong interaction between the potent analogs and VEGFR-2/HSP90 active sites inspiring these congeners to be potential drug candidates in cancer treatment.