review · European Archives of Psychiatry and Clinical Neuroscience
An umbrella review synthesised evidence from 63 systematic reviews to examine cognitive impairment and related factors in people living with schizophrenia. The compiled evidence indicates that individuals with schizophrenia experience greater cognitive deficits than both healthy controls and people with affective disorders. These cognitive difficulties are also present in individuals experiencing first-episode psychosis and those who are free of psychotropic medication. The most pronounced deficits emerge in processing speed, verbal memory, and working memory. Furthermore, more severe cognitive impairment correlates with poorer everyday functionality, reduced clinical insight, aggressive behaviour, and a history of childhood trauma. Methodological assessment indicated that the majority of the underlying systematic reviews were of moderate quality.
Cognitive deficits severely affect daily living and personal autonomy for individuals with schizophrenia. Clarifying which cognitive areas are most affected, such as memory and processing speed, helps healthcare professionals understand the clinical profile of the condition beyond typical symptoms. Recognising links to reduced insight and lower functioning underscores the broad impact of cognitive health on patient wellbeing and recovery.
The abstract does not indicate an application pathway.
AI-generated from the published abstract. Always read the original work before citing.
Cognitive impairment is one of the core symptoms of schizophrenia. Quite a number of systematic reviews were published related to cognitive impairment in people with schizophrenia (PWS). This umbrella review, therefore, aimed at reviewing and synthesizing the findings of systematic reviews related to domains of cognition impaired and associated factors in PWS. We searched four electronic databases. Data related to domains, occurrence, and associated factors of cognitive impairment in PWS were extracted. The quality of all eligible systematic reviews was assessed using A MeaSurement Tool to Assess methodological quality of systematic Review (AMSTAR) tool. Results are summarized and presented in a narrative form. We identified 63 systematic reviews fulfilling the eligibility criteria. The included reviews showed that PWS had lower cognitive functioning compared to both healthy controls and people with affective disorders. Similar findings were reported among psychotropic free cases and people with first episode psychosis. Greater impairment of cognition was reported in processing speed, verbal memory, and working memory domains. Greater cognitive impairment was reported to be associated with worse functionality and poor insight. Cognitive impairment was also reported to be associated with childhood trauma and aggressive behaviour. According to our quality assessment, the majority of the reviews had moderate quality. We were able to find a good number of systematic reviews on cognitive impairment in PWS. The reviews showed that PWS had higher impairment in different cognitive domains compared to healthy controls and people with affective disorders. Impairment in domains of memory and processing speed were reported frequently.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1007/s00406-022-01416-6
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
