article · Frontiers in Neurology

Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild–moderate traumatic brain injury patients and factors associated

Hervé Monka Lekuya
Larrey Kasereka Kamabu
Fredrick Makumbi
Gift Ahimbisibwe
David Patrick Kateete
Moses Galukande
Stephen Cose
Jelle Vandersteene
Marjorie Nakibuule
Anthony T. Fuller
Geoffrey Olweny
Emmanuel Biryabarema
Edward Baert
Anthony Kirabira
Jean-Pierre Okito Kalala

20244 citationsOpen accessMakerere University

Abstract

Delayed surgical intervention beyond 48 h post-injury in mild-moderate TBI patients results in a significantly increased postoperative inflammatory response, as evidenced by elevated serum levels of TNF-<i>α</i> and IL-6. Neurological deficits, PTS, reduced hemoglobin rate, and extra-axial intracranial hemorrhage are factors associated with this heightened response.

Research topics

Traumatic Brain Injury and Neurovascular Disturbances
Anesthesia and Neurotoxicity Research
Cardiac, Anesthesia and Surgical Outcomes

Sustainable Development Goals

1No Poverty

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DOI: 10.3389/fneur.2024.1484742

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