Causes Responsible For Failure of Fundoplication: A Meta-Analysis

Abstract

Abstract Background GERD is a very common disease nowadays. When medications like Proton Pump Inhibitors fail, Surgery becomes the treatment of choice. Objective To review and study the most common causes responsible for failure of Fundoplication and development of the most common postoperative complications (recurrence of reflux, dysphagia and gas-bloat syndrome). Patients and Methods Types of studies Published studies about the complications of Laparoscopic Fundoplication (carried out in the period between 2000 – 2021). Types of participants Patients with clinically proven complications like GERD, belching, dysphagia or unintentional slipping after Fundoplication. Results A copy of each paper identified was obtained, and relevant data was Abstracted for a quantitative overview. In case of discrepancies or when the information presented in a study is unclear, Abstraction by a second reviewer was sought to resolve the discrepancy. All included articles was assessed for quality regarding methodological strength as per the 2009 Cochrane collaboration updated guidelines for systematic reviews. Conclusion According to our results, paraesophageal hernia in addition to, disruption and tight wrap are significant causes of failure of Nissen fundoplication.