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review · ecancermedicalscience

Cancer stem cells and post-therapy tumour recurrence: a systematic review of mechanistic pathways and translational gaps

2025Open accessMohammed V University

Abstract

CSC-driven recurrence is a multifaceted and dynamic process shaped by epigenetic, transcriptional, metabolic and immunologic adaptations. Single-target strategies are unlikely to achieve durable eradication. Future research must prioritise multi-targeted approaches, integrate CSC endpoints into clinical trials and develop predictive biomarkers of CSC burden. Addressing CSC-mediated relapse is essential for advancing precision oncology and achieving lasting therapeutic responses.

Research topics

  • Cancer Cells and Metastasis

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DOI: 10.3332/ecancer.2025.2016

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