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article · Frontiers in Aging Neuroscience

Brain lipidomics for region-specific biomarker discovery in neurodegenerative diseases

2026Open accessAddis Ababa University

Abstract

This study provides a comprehensive overview of disease- and region-specific alterations in the brain lipidome of AD, HD, and PD. The identified lipid species-PS (16:1/24:0;O1), PS (O-17:0/22:6), and PI (18:1/18:1)-may serve as promising candidate biomarkers for NDs diagnosis and warrant further mechanistic and longitudinal validation with large data set.

Research topics

  • Metabolomics and Mass Spectrometry Studies
  • Sphingolipid Metabolism and Signaling
  • Fatty Acid Research and Health

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DOI: 10.3389/fnagi.2026.1757306

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