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review · RSC Advances

Bisphenol A (BPA) toxicity assessment and insights into current remediation strategies

202424 citationsOpen accessNnamdi Azikiwe University

In plain language

Bisphenol A is an industrial chemical commonly present in polycarbonate plastics and epoxy resins, with widespread contamination in water environments. In the human body, exposure leads to cellular changes in the brain linked to behavioural issues, endocrine disruption, reduced fertility, and vulnerability to substance dependence. To counter water contamination, several remediation strategies are available, including biological breakdown by bacteria, membrane filtration, adsorption, coagulation, ozonation, and photocatalysis. Bacterial action generates intermediates and products with reduced toxicity, while chemical and physical methods successfully break down the contaminant. However, current technologies often face a trade-off where high removal efficiency compromises processing throughput. Addressing this bottleneck for scalable deployment requires process intensification, combining multiple treatment techniques into integrated systems capable of delivering high degradation rates alongside high throughput.

Key takeaways

  • Bisphenol A from plastics alters cellular function in the brain, contributing to endocrine disorders, reduced fertility, and behavioural changes.
  • Bacterial degradation converts the compound into less toxic intermediates and end products.
  • Physical and chemical treatments such as filtration, adsorption, ozonation, and photocatalysis achieve effective aqueous degradation.
  • Existing remediation technologies face an operational trade-off between achieving high removal efficiency and maintaining high throughput.
  • Combining multiple treatment methods via process intensification is recommended to support scalable water remediation.

Why it matters

Bisphenol A is a widespread environmental pollutant that poses severe health risks, including reproductive, neurological, and hormonal damage. Understanding how to neutralise this compound in water supplies is crucial for protecting public health and ecosystems. Highlighting the balance between treatment speed and thoroughness helps guide the design of more effective, large-scale water purification systems capable of removing hazardous plastic additives before they reach communities.

Commercialisation angle

The review targets water treatment operators and environmental engineers addressing industrial effluent and contaminated water bodies. Real-world application remains at a developmental stage: while individual removal methods such as ozonation, filtration, and bacterial treatment are proven, commercial deployment at scale requires developing intensified, hybrid process systems that overcome current trade-offs between throughput and removal efficiency.

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Abstract

Bisphenol A (BPA) raises concerns among the scientific community as it is one of the most widely used compounds in industrial processes and a component of polycarbonate plastics and epoxy resins. In this review, we discuss the mechanism of BPA toxicity in food-grade plastics. Owing to its proliferation in the aqueous environment, we delved into the performance of various biological, physical, and chemical techniques for its remediation. Detailed mechanistic insights into these removal processes are provided. The toxic effects of BPA unravel as changes at the cellular level in the brain, which can result in learning difficulties, increased aggressiveness, hyperactivity, endocrine disorders, reduced fertility, and increased risk of dependence on illicit substances. Bacterial decomposition of BPA leads to new intermediates and products with lower toxicity. Processes such as membrane filtration, adsorption, coagulation, ozonation, and photocatalysis have also been shown to be efficient in aqueous-phase degradation. The breakdown mechanism of these processes is also discussed. The review demonstrates that high removal efficiency is usually achieved at the expense of high throughput. For the scalable application of BPA degradation technologies, removal efficiency needs to remain high at high throughput. We propose the need for process intensification using an integrated combination of these processes, which can solve multiple associated performance challenges.

Research topics

  • Effects and risks of endocrine disrupting chemicals
  • Microplastics and Plastic Pollution
  • Toxic Organic Pollutants Impact

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DOI: 10.1039/d4ra05628k

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