article · Frontiers in Bioengineering and Biotechnology
Periodontitis is an inflammatory condition triggered by an infectious microbiome and host defence responses, resulting in damage to the periodontium. Treating the disease remains difficult due to complex pathological mechanisms and oral processes, such as eating and saliva flow, which quickly clear medications from the affected site. Advanced local delivery technologies are therefore required to improve treatment retention and efficacy. Hydrogels offer significant potential for periodontal therapy because they are biodegradable, biocompatible, and easily applied to target tissues. Research has increasingly concentrated on intelligent thermosensitive hydrogels. These materials undergo local sol-gel transitions and modulate drug release in response to temperature changes. Examining the design and construction of these smart hydrogels highlights new approaches for periodontal tissue regeneration, while addressing the clinical challenges and research requirements needed to translate these delivery systems into practical therapeutic use.
Periodontal disease causes significant tissue and bone destruction in the mouth, but standard drug therapies are easily washed away by saliva and food. Developing temperature-responsive hydrogels that stay in place and release drugs on demand could dramatically improve treatment outcomes, offering patients better tissue regeneration and more reliable relief from chronic oral inflammation.
This work points towards advanced local delivery products for dental clinicians treating periodontitis and supporting oral bone regeneration. Because the abstract outlines a review of design strategies, challenges, and future study objectives rather than reporting finished formulations or trial data, the technology remains at an early concept and development stage, still distant from clinical adoption and commercial manufacture.
AI-generated from the published abstract. Always read the original work before citing.
Periodontitis is an inflammation-related condition, caused by an infectious microbiome and host defense that causes damage to periodontium. The natural processes of the mouth, like saliva production and eating, significantly diminish therapeutic medication residency in the region of periodontal disease. Furthermore, the complexity and diversity of pathological mechanisms make successful periodontitis treatment challenging. As a result, developing enhanced local drug delivery technologies and logical therapy procedures provides the foundation for effective periodontitis treatment. Being biocompatible, biodegradable, and easily administered to the periodontal tissues, hydrogels have sparked substantial an intense curiosity in the discipline of periodontal therapy. The primary objective of hydrogel research has changed in recent years to intelligent thermosensitive hydrogels, that involve local adjustable sol-gel transformations and regulate medication release in reaction to temperature, we present a thorough introduction to the creation and efficient construction of new intelligent thermosensitive hydrogels for periodontal regeneration. We also address cutting-edge smart hydrogel treatment options based on periodontitis pathophysiology. Furthermore, the problems and prospective study objectives are reviewed, with a focus on establishing effective hydrogel delivery methods and prospective clinical applications.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.3389/fbioe.2024.1384326
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
