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article · Cell Death Discovery

Berry-derived gold nanoparticles induce integrated ROS-mediated apoptosis, immune modulation, and transcriptomic remodeling in 4T1 triple-negative cancer cells

Abstract

/STAT3 pathway supporting transcriptomic and transcriptional reprogramming of 4T1 treated cells. Together, our findings uncover a new strategy to capture berry-derived polyphenols required to regulate apoptosis, autophagy, immune response, and metastasis-related gene networks in breast cancer, thereby underscoring the therapeutic potential of functionalized AuNPs as delivery platforms for dietary phytochemicals.

Research topics

  • Advanced Breast Cancer Therapies
  • Protein Degradation and Inhibitors
  • Cancer-related Molecular Pathways

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DOI: 10.1038/s41420-026-03023-z

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