article · SpringerPlus
A study was conducted at Mekelle Hospital in Northern Ethiopia to identify the types of bacteria causing bloodstream infections in febrile patients and to determine their susceptibility to antibiotics. Researchers analysed blood samples from 514 febrile patients between March and October 2014. They found that 28% of these patients had a bacterial infection in their blood. The most common bacteria identified were Staphylococcus aureus, Coagulase-negative staphylococci, Escherichia coli, Citrobacter spp., and Salmonella typhi. A significant proportion, 59%, of the isolated bacteria showed multi-drug resistance. High resistance was observed against Trimethoprim-sulphamethoxazole, Oxacillin, Ceftriaxone, and Doxycycline, while most isolates were sensitive to Gentamicin, Ciprofloxacin, and Amoxicillin clavulanic acid. All gram-positive isolates were sensitive to vancomycin.
Understanding the specific bacteria causing bloodstream infections and their resistance patterns is crucial for effective patient treatment. This information helps healthcare providers choose appropriate antibiotics, reducing treatment failures, patient mortality, and the further spread of drug-resistant infections within the community.
The abstract highlights the need for periodic surveillance of bacterial pathogens and their antibiotic susceptibility patterns. This research provides foundational data for public health organisations to update treatment guidelines and inform antibiotic stewardship programmes. It is early-stage research, providing epidemiological data rather than a direct product or service, but it is vital for informing clinical practice and policy development.
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Bacterial bloodstream infections are a major public health problem, which leads to high morbidity and mortality of patients. On time diagnosis and appropriate medication will be the best way to save the lives of affected ones. The aim of the present study was to determine the bacterial profile of bloodstream infections and their antibiotic susceptibility pattern in Mekelle Hospital. Cross sectional study method was carried out in 514 (269 females and 245 males) febrile patients in Mekelle hospital from March to October 2014. Standard bacteriological methods were used for blood collection, bacterial isolation and antimicrobial susceptibility pattern. Out of the total 514 febrile patients, 144 (28%) culture positive were isolated. Staphylococcus aureus 54 (37.5%), Coagulase-negative staphylococci 44 (30.6%), Escherichia coli 16 (3.1%), Citrobacter spp. 9 (1.7%) and Salmonella typhi 8 (1.6%) were the most dominant isolates, collectively accounting for >90% of the isolates. Antimicrobial resistance pattern for gram positive and gram negative bacteria was 0-83.3% and 0-100%, respectively. High resistance was seen to Trimethoprim-sulphamethoxazole 101 (70.1%), Oxacillin 65 (62.5%), Ceftriaxone 79 (58.9%) and Doxycycline 71 (49.3%). Fifty-nine percent of the isolated bacteria in this study were multi drug resistant. Most bacterial isolates were sensitive to Gentamicin, Ciprofloxacin and Amoxicillin clavulanic acid. All gram positive isolates in this current study were sensitive to vancomycin. Prevalence of bacterial isolates in blood was high. It also reveals isolated bacteria species developed multi drug resistance to most of the antibiotics tested, which highlights for periodic surveillance of etiologic agent, antibiotic susceptibility to prevent further emergence and spread of resistant bacterial pathogens.
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DOI: 10.1186/s40064-015-1056-x
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