Autoantibodies in a Cohort of Egyptian Patients with Inflammatory Muscle Disease

Abstract

Abstract Objective Autoimmune myopathies can present with diverse phenotypes and extra muscular systems affection, our aim is the illustration of different clinical pictures, Magnetic resonance findings and laboratory data in relation to myositis auto antibodies in a cohort of Egyptian patients. Methods This descriptive observational study was conducted in Ain Shams university hospital over a period of 2 years, a total of 77 patients were recruited and 10 control samples were collected. Results A total of 34 patients tested positive for Myositis Auto-antibodies, they showed female sex predominance (61.7%), the mean values for their age and age of onset were 28.618±14.346 and 23.574±13.584 respectively. Conclusion Autoantibodies are an important tool in diagnosis and management of immune mediated myopathy, especially when paired with clinical picture, radiological and other laboratory findings, our studied sample showed higher percentage of inflammatory myopathy subtypes associated with connective tissue disorders followed by Immune medicated necrotizing myopathy subtype then anti-synthetase syndrome antibodies.