Association of Hand-Grip Strength and Non-Alcoholic Fatty Liver Disease Index in Older Adults

Abstract

Abstract Background The association between grip strength (GS) and non-alcoholic fatty liver disease (NAFLD) has been reported by recent epidemiological studies, however, the results of these studies are inconsistent. Aim of the Work Verification of the association between hand-grip strength and indicators of non- alcoholic hepatic steatosis and fibrosis in older adults. Patients and Methods A total of 110 older adults who had their diagnosis of NAFLD (hepatic steatosis and fibrosis) that confirmed by non-invasive method and attended or admitted to the Hepatology Unit were enrolled. Calculation of fatty liver index and NAFLD score for all patients was performed. Results There was statistically significant association between significant hepatic fibrosis and FLI and hand-grip strength; FLI was elevated (positive correlation) and hand-grip strength was decreased (negative correlation). Presence of significant hepatic fibrosis was statistically significant associated with decreased ALT and platelet levels (negative correlation) and increased AST/ALT ratio and GGT levels (positive correlation). Conclusion There is significant clinical evidence that the HGS is inversely associated with the incidence of NAFLD. NAFLD can be associated with muscular impairment in older adults, as demonstrated by lower muscle strength.