ASSOCIATION BETWEEN LEFT VENTRICULAR DIASTOLIC DYSFUNCTION AND ACUTE KIDNEY INJURY IN SEPTIC SHOCK PATIENTS

Abstract

Septic shock is life-threatening and time-dependent condition that requires timely management to reduce mortality. Cardiac dysfunction is common in patients with sepsis in an entity called sepsis-induced cardiomyopathy with an incidence ranging from 40% to 60%. Left ventricular (LV) dysfunction can be a serious obstacle in restoring organ perfusion when treating patients with sepsis. Indeed, diastolic dysfunction is associated with increased mortality in patients with sepsis. Sepsis-associated AKI patients may experience any of several disease trajectories, including renal recovery, survival with diminished kidney function, or death. The outcome depends greatly on the severity of the kidney injury.Left ventricular diastolic dysfunction (LVDD), which is reflected by early diastolic velocity of mitral inflow to early diastolic mitral annular velocity (E/e′) and left ventricular ejection fraction (LVEF), are related to the risk of AKI and mortality, and E/e′ is a significant predictor of adverse kidney events under different clinical conditions.AIM OF THE WORK:The aim of the present study was to investigate the association of left ventricular diastolic dysfunction with septic acute kidney injury among septic shock patients.