article · BioMed Research International

Association between Interleukin-6 Gene Polymorphism (rs1800795 and rs1800796) and Type 2 Diabetes Mellitus in a Ghanaian Population: A Case-Control Study in the Ho Municipality

Christian Obirikorang
Emmanuel Mawuli Nattah
Evans Asamoah Adu
Shadrack Asiedu Coffie
William K. B. A. Owiredu
Linda Ahenkorah Fondjo
Samuel Ametepe
James Osei-Yeboah
Priscilla Essandoh
Kwabena Obeng Duedu
Sylvester Yao Lokpo
Esther Ngozi Adejumo
Precious Kwablah Kwadzokpui

20247 citationsOpen accessBabcock University

Abstract

The GC genotype and mutant C allele are risk genetic variants associated with type 2 DM in the Ghanaian population. The rs1800796 GC variant, dietary sugar intake, and exercise status appear to contribute significantly to the variations in circulating IL-6 levels but with weak effect sizes.

Research topics

Adipokines, Inflammation, and Metabolic Diseases
Diabetes and associated disorders
Genetic Associations and Epidemiology

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1155/2024/3610879

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