article · Scientific Reports
Diabetic wounds heal slowly and frequently lead to severe complications such as amputations. A combination therapy combining selenium nanoparticles and platelet-rich plasma was evaluated in a diabetic mouse model over twenty-eight days. Selenium nanoparticles provide antioxidant and antimicrobial effects, while platelet-rich plasma provides high concentrations of growth factors. Healing progression was monitored using photographic assessments, scoring tools, and tissue analysis. Both treatments enhanced wound recovery individually, but their combined application produced a synergistic effect that significantly accelerated the healing process. This dual approach demonstrated substantial potential to overcome impaired healing pathways in diabetic conditions. By expediting tissue repair, the combination offers a promising therapeutic strategy to improve clinical outcomes for diabetic wounds and reduce the incidence of lower-limb amputations related to diabetic foot ulcers.
Slow-healing wounds in diabetic individuals often lead to chronic ulcers and limb amputations. Developing accelerated healing strategies addresses a critical clinical challenge. By demonstrating that combined nanoparticle and biological plasma treatments accelerate tissue repair in preclinical models, this research highlights an effective pathway towards preventing severe diabetic complications and improving patient mobility.
The findings could enable advanced wound-care products, such as specialised topical formulations or bioactive dressings, for clinicians treating diabetic foot ulcers. The research remains at an early preclinical stage in mouse models. Extensive clinical trials and regulatory development will be required before this therapeutic combination can move towards real-world medical use.
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Diabetic wound healing is sluggish, often ending in amputations. This study tested a novel, two-punch therapy in mice-Selenium nanoparticles (Se NPs) and platelet-rich plasma (PRP)-to boost healing. First, a mouse model of diabetes was created. Then, Se NPs were crafted for their impressive antioxidant and antimicrobial powers. PRP, packed with growth factors, was extracted from the mice's blood. Wound healing was tracked for 28 days through photos, scoring tools, and tissue analysis. Se NPs alone spurred healing, and PRP added extra fuel. Furthermore, when used in combination with PRP, the healing process was accelerated due to the higher concentration of growth factors in PRP. Notably, the combination of Se NPs and PRP exhibited a synergistic effect, significantly enhancing wound healing in diabetic mice. These findings hold promise for the treatment of diabetic wounds and have the potential to reduce the need for lower limb amputations associated with diabetic foot ulcers. The innovative combination therapy using Se NPs and PRP shows great potential in expediting the healing process and addressing the challenges of impaired wound healing in individuals with diabetes. This exciting finding suggests this therapy could change diabetic wound management, potentially saving limbs and improving lives.
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DOI: 10.1038/s41598-024-54064-2
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