Assessment Of Serum Resolvin (E1) Level in Hashimoto’s Thyroiditis

Abstract

Background: Hashimoto's thyroiditis (HT) is most prevalent autoimmune thyroid condition worldwide and main etiology of hypothyroidism in iodine-sufficient areas. present study aimed to identify role of Resolvin E1 (REV1) in protecting thyroid gland against increased levels of thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb) in patients with euthyroid HT.Subjects and methods: This case-control study was conducted on 76 subjects allocated into two groups. Patient group included 38 euthyroid Hashimoto’s thyroiditis patients (TPO Ab and/or TgAb +ve). control group included 38 age and sex-matched healthy non-diseased individuals. Resolvin E1 samples were collected on admission. Results: There was a substantial variance between the groups concerning TPOAbs and TgAbs with increased anti-TPO and TgAbs values in the case group and reduced RVE1 levels in the cases group p<0.001). There was a substantial inverse association between Serum RVE1 levels with TPOAbs and TgAbs (P=0.02 and 0.03, respectively). In univariate regression analysis, age (odd ratio (OR)=1.54, 95 % Confidence Interval (CI)=2.47–3.43, p=0.002), sex (OR=1.18, CI=10.80–12.22, p=0.016), Tg-Abs (OR= 1.11, CI= 1.31–3.47,p< 0.001), and RVE1 (OR=1.01, CI of 11.58–2.42, p=0.007) were significant predictors for increasing TPO Ab levels in euthyroid Hashimoto’s thyroiditis patients. In multivariate regression analysis, Tg-Abs (OR = 1.13, 95 % CI = 1.81–4.33, P = 0.003) and RVE1 (OR = 1.01, 95 % CI = 1.31–3.47, P = 0.006) were significant predictors for increasing TPO Ab levels in euthyroid Hashimoto’s thyroiditis patients.Conclusion: HT cases had substantially lower serum RVE1 concentrations. RVE1 may also offer protection against elevated TgAb values.