Assessment of serum cardiac biomarkers [cTn-1, hs-CRP, CKMB] in patients attending Federal Medical Center Owerri, Imo State, South-East Nigeria

Abstract

Abstract Background: Despite advancements in techniques, technologies, and measurement modalities, accurately assessing blood pressure remains challenging. However, certain unique biomarkers have been extensively studied and consistently demonstrated their ability to predict significant clinical outcomes across various disorders. Aim: This study aimed to assess serum cardiac biomarkers in Federal Medical Center (FMC) Owerri patients. Materials and Methods: One hundred twenty-seven hospital attendees aged 25–66 years and older voluntarily participated in the study. Among them, 80 were hypertensive, while 47 were normotensive. Blood samples (5 mL) were collected from each participant, and the levels of cardiac troponin I (cTnI), high-sensitivity C-reactive protein (hs-CRP), and creatine kinase MB (CKMB) were analyzed using standard laboratory procedures. Results: The hypertensive group showed significantly higher ( P < 0.05) systolic blood pressure (SBP), pulse pressure (PP), diastolic blood pressure, mean arterial pressure, and serum levels of cTnI, hs-CRP, and CKMB compared to the normotensive group. Conclusion: This study found that hypertension was more prevalent among female attendees at FMC Owerri, as reflected by the elevated levels of the evaluated biomarkers in this group.