Assessed the Liver Injury Biomarker Following Candida Infection in Female Diabetic Rats

Abstract

Candidasis, an important cause of morbidity and death, has been on the rise globally in the last several decades, particularly among very sick patients. Because of its immunosuppressive effects, the metabolic disease diabetes mellitus (DM) makes patients more likely to contract fungal infections, such as those caused by Candida sp. Only a small number of studies have established a causal relationship between vaginal Candida infection and liver injury. Researchers in this study looked at how a vaginal Candida infection affected a biomarker for liver damage in Wistar rats. The researchers formed two groups of ten female Wistar albino rats each, out of a total of twenty. We used rats that did not undergo any treatment as controls. The female rats in the infected group will receive an intraperitoneal injection of 120 mg/kg of alloxan to suppress their immune system. The next step is to confirm that the glucose levels are high. Next, the vaginal opening is inoculated with the isolated yeast C. albicans at a concentration of approximately 5 x 108 and allowed to grow for 5 weeks. They had their blood tested for total bilirubin, total protein, alanine aminotransferase, and aspartate aminotransferase. Disturbed and distinct from the control group were the liver injury biomarkers. Finally, vaginal Candida infections damage the livers of Wistar rats.