article · Virology Journal

Aspergillus fumigatus secretes a protease(s) that displays in silico binding affinity towards the SARS-CoV-2 spike protein and mediates SARS-CoV-2 pseudovirion entry into HEK-293T cells

20243 citationsOpen accessUniversity of the Free State

Abstract

These results suggest that A. fumigatus secretes a protease(s) that activates the SARS-CoV-2 spike protein. Importantly, should these two infectious agents co-occur, there is the potential for A. fumigatus to activate the SARS-CoV-2 spike protein, thus aggravating COVID-19 development.

Research topics

Antifungal resistance and susceptibility
SARS-CoV-2 and COVID-19 Research
vaccines and immunoinformatics approaches

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DOI: 10.1186/s12985-024-02331-z

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