article · Menoufia Veterinary Medical Journal
Acridine is a naturally occurring alkaloid featuring three fused rings with a nitrogen atom in the central ring. As heteroaromatic compounds, acridines interact directly with nucleic acids and proteins, making them useful for targeting biopolymers in cancer treatments and gene delivery systems. Because acridines also interact directly with diverse enzymes, they show potential as therapeutic agents for neurodegenerative conditions, inflammation, immunological disorders, protozoal infections, and diabetes. Additionally, arylidene derivatives undergo various chemical processes, including reductive alkylation, nucleophilic addition, electrophilic substitution, reduction, oxidation, and photoalkylation. Alongside acridine, gallic acid is an abundant compound found in edible and herbal plant sources. Gallic acid exhibits anti-inflammatory and antioxidant activities across several metabolic disorders. Together, the documented evidence highlights the antidiabetic and broader therapeutic properties of both gallic acid and acridine compounds across a wide range of human health applications.
Understanding the biochemical mechanisms of natural compounds such as acridines and gallic acid supports the identification of new drug candidates. Because these molecules target enzymes, proteins, and nucleic acids, they provide versatile chemical foundations for addressing widespread health challenges, ranging from cancer and neurodegenerative illnesses to chronic inflammation and metabolic conditions like diabetes.
This work points to prospective applications in therapeutic drug design and gene delivery for pharmaceutical developers targeting cancer, diabetes, and inflammatory disorders. Because the text presents a broad review of known chemical properties and disease applications rather than specific formulation or trial data, these compounds remain at an early exploratory stage of biomedical research, far from immediate market deployment.
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Acridine is one of the simple alkaloids found in nature, has three fused rings with a nitrogen atom on the middle ring. Acridines are heteroaromatic compounds, which interact with both nucleic acids and proteins. The targeting of these biopolymers is broadly applied in cancer therapy and gene delivery. Interestingly, due to direct interactions of acridines with various enzymes, acridines can be suitable drugs for treatment of neurodegenerative diseases, inflammation, immunological disorders, protozoal diseases, diabetes, etc. Numerous processes, including reductive alkylation, nucleophilic addition, electrophilic substitution, reduction, oxidation, and photoalkylation, occur with arylidene.Gallic acid (GA) is a very rich in many edible and herbal plants and has an antioxidative and anti-inflammatory effects on some metabolic disorders. To have a better understanding of its antidiabetic properties and its therapeutic important on human health care, the available review supporting the effective properties of GA. This review outlined the uses of acridine and Gallic acid for treatment of different diseases.
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DOI: 10.21608/vmmj.2025.383623.1047
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