article · Organic Letters
From the leaves of a yet undescribed Congolese Ancistrocladus species, two novel naphthylisoquinoline dimers, spirombandakamines A<sub>1</sub> (1) and A<sub>2</sub> (2), were isolated, together with a new, but "classical" dimer, mbandakamine B<sub>2</sub> (3). The cage-like stereostructures of 1 and 2 were established by combining spectroscopic, chemical, and chiroptical methods with quantum-chemical ECD calculations. Their unique molecular frameworks may originate from "open-chain" dimers, such as 3, by an oxidation-induced cascade of reactions. They possess strong antiprotozoal properties.
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DOI: 10.1021/acs.orglett.7b03473
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