Antihypertensive, Ameliorating Effect on Lipid Profile and Oxidative Stress Markers of Aqueous Extract of Pleurotus floridanus in Rats

Abstract

Context: Hypertension is a silent disease whose prevalence is constantly increasing. Its management is not always controlled. Thus, the objective of this work was to study the antihypertensive effect of the aqueous extract of the edible mushroom Pleurotus floridanus on the lipid profile and some markers of oxidative stress in Wistar rats. Methods: Phytochemical screening and the study of toxicity of the aqueous extract of Pleurotus floridanus were previously performed. The antihypertensive effect of the aqueous extract of Pleurotus floridanus (1000 mg/Kg of BW) was evaluated on Wistar rats, by co-administration of L-NAME (25 mg/Kg of BW) for three weeks. Hemodynamic parameters were measured once a week via the CODA system. Serum parameters such as lipid profile and oxidative stress markers (MDA, catalase, SOD) were evaluated. Results: The results showed that the aqueous extract of Pleurotus floridanus contained tannins, phenols, coumarins, flavonoids, glycosides, steroids and terpenoids and had no particular signs of toxicity. Co-administration of the aqueous extract and L-NAME in the test group resulted, as in the standard (captopril) group, in a moderate increase in systolic, diastolic and mean arterial blood pressure, significantly lower (P < 0.05) than that observed in the positive controls. Also, a significant decrease (P < 0.05) in heart rate during the last two weeks of treatment was observed in the test group. The administration of the aqueous extract regulated the lipid profile and serum stress markers like the reference drug. Conclusion: These results demonstrate the antihypertensive potential of the edible mushroom Pleurotus floridanus.