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article · PLoS ONE

Analysis and simulation study of the HIV/AIDS model using the real cases

202417 citationsOpen accessUniversity of the Free State

Abstract

We construct a model to investigate HIV/AIDS dynamics in real cases and study its mathematical analysis. The study examines the qualitative outcomes and confirms the local and global asymptotic stability of both the endemic equilibrium and the disease-free equilibrium. The model's criteria for exhibiting both local and global asymptotically stable behavior are examined. We compute the endemic equilibria and obtain the existence of a unique positive endemic equilibrium. The data is fitted to the model using the idea of nonlinear least-squares fitting. Accurate parameter values are achieved by fitting the data to the model using a 95% confidence interval. The basic reproduction number is computed using parameters that have been fitted or estimated. Sensitivity analysis is performed to discover the influential parameters that impact the reproduction number and the eradication of the disease. The results show that implementing preventive measures can reduce HIV/AIDS cases.

Research topics

  • Mathematical and Theoretical Epidemiology and Ecology Models
  • COVID-19 epidemiological studies
  • Adolescent Sexual and Reproductive Health

Sustainable Development Goals

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DOI: 10.1371/journal.pone.0304735

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