Amikacin exposure in MDR-TB patients in Uganda: Revisiting old drugs in a new era of resistance – A pharmacokinetic assessment

Abstract

This population-PK study shows that major differences in PK between Ugandan MDR-TB patients and those in the Global North are unlikely. Our findings reinforce the suitability of a one-compartment model for therapeutic drug monitoring in both high- and low-resource settings. Readily obtained aminoglycoside PK parameters in a limited resource setting facilitate future efforts in optimizing drug exposure with minimal toxicities, in the population most affected by the pandemic of TB.