Ameliorative Effect of Ethanolic Extract of Curcuma longa (Tumeric) on Hematology profile of N-nitrosodiethylamine Administration in Wistar Rats

Abstract

Abstract This present study compares the effect of ethanolic extract of Curcuma longa (EECL) and curcumin compound on the hematological profile of NDEA male and female Wistar rats. One hundred and twenty rats were randomly divided into twelve groups (n=5) for the experimental duration of 8 weeks. Group A,B,C,D,E and F received 100 mg/kg of NDEA each with 200 mg/kg, 400 mg/kg, 600 mg/kg EECL, 200 mg/kg curcumin compound and 100 mg/kg of syilbon (standard drug) respectively. Group G received 200 mg/kg of curcumin compound only, H received 200 mg/kg DMSO only, group I,J and K received 200 mg/kg, 400 mg/kg and 600 mg/kg of EECL while group L received only water. Animals were sacrificed at the end of 28 days of treatment. Blood samples were collected into labeled EDTA bottles for hematology analysis. There was significant decrease (P<0.05) in the white blood count (WBC), Mid-range absolute count (MID), granulocytes and platelet of the NDEA treated groups as compared with the control group in female leucogram as compared with male leucogram. The result of the erythrogram showed significant decrease (P>0.05) in red blood count (RBC) and hemoglobin (HGB), while Mean corpuscular hemoglobin concentration(MCHC),Mean corpuscular volume (MCV) and MCH concentration (MCHC) was significant increase (P<0.05) in NDEA group as compared with control in both male and female groups. the the findings suggests mitigative effect of ethanolic extract of Curcuma longa and pure curcumin compound on hematological dysfunctions in both male and female rats.