Advanced Pharmaceutical Delivery Systems: Utilizing Emulsification and Nanoprecipitation Techniques for Poly(lactic-co-glycolic acid) Nanoparticles.

Abstract

The pharmaceutical industry extensively uses the adaptable synthetic polymer known as poly (lactic-co-glycolic acid) (PLGA). These benefits have led to its use in drug delivery using nanoparticles (NPs) due to its biocompatibility and biodegradability polymer, which has a wide range of uses as a carrier for creating polymeric nanoparticle drug delivery systems. This article overviews the various PLGA nanoparticles (PNPs) and their preparation techniques, including emulsification-solvent evaporation (Single or Double), emulsification solvent diffusion, emulsification reverse salting out, and nanoprecipitation. A brief overview of PNPs' physicochemical behaviour and morphology, drug loading, particle size and distribution, stability, surface charge, drug release, and cytotoxicity evaluation is provided. A diagram of the significant uses of PNP in various drug delivery systems is presented using the results of this survey in conjunction with surface modifications of PNP. This review discusses the preparation techniques and characteristics of different drugs, polymers, and stabilisers used in detail and their benefits for industry.