article · Pharmaceutics
<b>Background/Objectives</b>: Cocrystallisation is a well-established path for altering the physicochemical properties and bioavailability of active pharmaceutical ingredients (APIs). A common side effect of anti-tubercular medicines is the depletion of group B vitamin reserves in TB patients. Co-administration of supplements such as pyridoxine (vitamin B<sub>6</sub>) during TB therapy may be used to ameliorate the harmful side effects of vitamin B<sub>6</sub> deficiency. <b>Methods</b>: Mechanochemical grinding and solvent evaporation experiments using pyridoxine (PN) with 4-aminosalicylic acid (PAS) and separately with pyrazinecarboxylic acid (PCBA) were conducted. The bulk powder and crystal analysis was performed using FTIR, PXRD, DSC, TGA and SCXRD. <b>Results</b>: The isolation and characterization of two multicomponent salts containing pyridoxine, i.e., PN-PAS·H<sub>2</sub>O and PN-PCBA, were completed. Mechanochemistry is an efficient method for the preparation of cocrystals. <b>Conclusions</b>: The drug-vitamin combinations may be useful for the development of new treatment regimens with potentially improved therapeutic outcomes and reduced adverse effects.
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DOI: 10.3390/pharmaceutics18030297
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