A study of (IL-23R) Genetic variant (rs11805303) In Egyptian Patients with Rheumatoid Arthritis

Abstract

Background: Objective to explore the link between disease activity and the IL-23R genetic variation (rs11805303) in a cohort of Egyptian individuals at risk for rheumatoid arthritis. Patient and Methods: One hundred participants, ranging in age from thirty to sixty, 56 of whom had RA and 44 of whom were apparently healthy matched in age and sex with patients, were documented in the methodology. All participants were genotyped using PCR/RFLP for the genetic variation. Kruskal-Wallis and Mann-Whitney tests, as well as chi-square (χ2), Monte Carlo tests, and logistic regression, were used to examine the data. Results: The prevalence of the rs11805303 TT genotype was 21.4% in RA patients, which is greater than in controls (2.3 % ). A much greater risk of RA was associated with the CT genotype (1.77 times) and the TT genotype (5.25 times) compared to the CC genotype. Conclusion: Researchers found that compared to apparently healthy controls, RA patients are more likely to have the IL-23R rs11805303 TT genetic variation. Additionally, greater levels of anti-CCP were associated with the TT genotype, but higher levels of acute phase reactants and disease activity scores are associated with the CC genotype.