A structural blueprint for antibacterial discovery: microwave- and ultrasound-assisted synthesis of pyrrolidine-fused quinoxalines as novel inhibitors of DNA gyrase and biofilm

Abstract

values were significantly less than that of ciprofloxacin (77.3, 87.6, and 65.5 µM, respectively). To determine the best drug-like qualities, the study examined the physicochemical and pharmacokinetic features of active compounds. Molecular docking simulation experiments were also conducted to comprehend the binding interactions and mechanisms of action of these hits.