A Sensitive Voltammetric Sensor for Improved Simultaneous Determination of Moxifloxacin Hydrochloride and Paracetamol

Abstract

An electrochemical sensor was prepared using a platinum (Pt) electrode modified with a binary layer of poly(1,5-diaminonaphthalene) (p-1,5-DAN) and platinum nanoparticles (PtNPs). The obtained sensor was investigated using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), square wave voltammetry (SWV), and electroactive surface area measurements (EASA). The PtNPs/p-1,5-DAN/Pt electrode was applied for individual and simultaneous determination of Paracetamol (PCT) and moxifloxacin hydrochloride (MFH) in aqueous solutions of Britton–Robinson buffer (BRB). Under optimized conditions, the PtNPs/p-1,5-DAN/Pt electrode exhibited excellent sensing ability toward the oxidation of PCT and MFH with linear responses with ranges of 1–1000 μ M and 10–1000 μ M and detection limits of 0.09 μ M and 0.10 μ M, respectively. PtNPs/p-1,5-DAN/Pt exhibits good repeatability, reproducibility, and acceptable stability and was found to be applicablefor simultaneous determination of PCT and MFH in pharmaceutical formulations and spiked biological fluids.