review · Natural Product Research
Marshall (Ranunculaceae), commonly known as yellowroot, is a deciduous shrub native to the eastern hardwood forests of the United States, thrives in wet, shady settings. This plant, which usually reaches a height of one to three feet, is distinguished by its yellow roots, which have long been used extensively in Native American medicine, especially by the Cherokee people. Traditionally, roots were used as a tonic and to treat ulcers, cramps, and jaundice. Numerous bioactive substances, such as triterpenes, phenolics, flavonoids, alkaloids, and sterols, are present in yellowroot extracts. The plant's historic medicinal benefits are supported by the therapeutic potential of berberine, which stands out among these. Because of its wide variety of bioactive compounds, yellowroot has cultural significance as well as potential for future study in contemporary medicine. Its historical records as a remedy emphasise its importance in both conventional and modern medicine.
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DOI: 10.1080/14786419.2025.2552203
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