A concentrated phenolic compounds extract from Khaya grandifoliola CDC exhibits anti-oxidant and anti-TNFα activities

Abstract

A concentrated phenolic compounds extract (KPE) from the plant Khaya grandifoliola was assessed in vitro for antioxidant and anti-inflammatory properties and its effect on erythrocytes Plasma Membrane Redox System (PMRS). Phenolic compounds quantity per g of dry matter (DM) were total phenols (57. 93±0.42mg EGA) and flavonoids (2.84±0.04 mg EQ). Antiradicalar half scavenging concentrations were 6.25±0. 07 μg/mL and 11.65±0.92 μg/mL for DPPH° and HO° tests, respectively. Total Antioxidant Capacity was 76.82±0.35 mgEq AA/g DM and half inhibitory concentrations (IC50) of 8.50±0.14 µg/mL, 8.7±0.14 µg/mL and 71.05±1.20 µg/mL found for inhibition of lipids and proteins oxidation and TNFα production in Jurkat T cells, respectively. KPE activated erythrocytes PMRS with an EC50 of 5.90±0.00 µg/mL. Conclusively, KPE may be suggested as potential ingredient of functional foods against health conditions involving oxidative stress and inflammation.