review · SINAI International Scientific Journal.
Background: Novasomes (Novs) are a novel lipid-based drug delivery system(LBDDS) for enhanced drug delivery. Those systems are composed of surfaceactive agents (SAA) and free fatty acids (FFA) that self-assemble into sphericalbilayer structures to encapsulate a variety of therapeutic drugs. Novs have beenextensively studied as drug carriers, including antifungals, antibiotics, anti-inflammatory, and anticancer drugs. They approved better solubility andpermeability, greater therapeutic efficacy, and diminished side effects whencompared to free drug formulations.Aims of this review: This review provides a thorough outlook, includingnovasomal constituents, development techniques, advantages and disadvantages,variant characterizations, routes of administration, pharmacological applications,and future prospects in the field of novasomal research.
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DOI: 10.21608/sisj.2025.442481
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