article · Journal of Clinical Medicine Research

A Complex Interplay of Tumor Microenvironment Could Enhance Cholangiocarcinoma Progression Even After Surgery: A Prospective Study

Asmaa M. Zahran
Aya Mohammed Mahros
Zeinab Albadry M. Zahran
Mohamed Ahmed Bashir
Amal Rayan
Heba M. Elmasry
Khaled Saad
Ahmed Soliman
Mohsen M Fageeh
Essam-Eldeen M O Mahran
Khalid Rezk
Ahmed Khalid Ibrahim
Mohamed Ahmed Rizk
Doaa A Gamal

2024Open accessKafr el-Sheikh University

Abstract

CCA has a desmoplastic microenvironment with complex immunologic topography and tumor-reactive stroma. The immune landscape of the peripheral blood mononuclear cells (PBMCs) in CCA patients before treatment could reflect the state of systemic immune function and response to treatments. Our results revealed that T-lymphocytes correlated with better prognosis while macrophages and PD-1<sup>+</sup> expression were associated with poor outcomes.

Research topics

Cholangiocarcinoma and Gallbladder Cancer Studies
Peptidase Inhibition and Analysis
MicroRNA in disease regulation

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DOI: 10.14740/jocmr5201

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