#6368 PLATELET TO LYMPHOCYTE RATIO AND SICKLE CELL NEPHROPATHY

Abstract

Abstract Background and Aims Platelet-to-lymphocyte ratio (PLR) was introduced as cheap and readily assessed biologic markers of subclinical inflammation in sickle cell disease. Microalbuminuria and hyperfiltration, early markers of Sickle cell nephropathy (SCN) have been reported to be associated with platelet-to-lymphocyte ratio (PLR). This association has not yet been assessed in Congolese Sickle cell disease (SCD) children. Therefore, the aim of the present study was to assess the association between PLR and early markers of kidney disease in SCD children living in the Democratic Republic of Congo (DRC). Method In this cross-sectional study, we have investigated 175 SCD children from four centers (Kinshasa university clinics, CMMASS, CMD Diamand, and Biamba Marie Mutumbo Dikembe) that give a comprehensive care to SCD patients. The PLR were calculated from full blood count. Elevated albuminuria and hyperfiltration, as the main outcomes of the study, were defined by urinary albumin/creatinine ratio (ACR) ≥30 mg/g and estimated glomerular filtration ratio (eGFR) >130 ml/min per 1.73 m2 for females and >140 ml/min per 1.73 m2 for males, respectively. Logistic regression analysis was used to assess the relationship between RPL and early sickle cell nephropathy. Results Of the 175 SCD children enrolled, 41(23.4%) and 67(38.3%) of them presented with abnormal albuminuria and hyperfiltration, respectively. RPL >130 was observed in 90 (51.4%) patients. RPL was strongly, significantly and independently associated with both abnormal albuminuria (aOR 3,381; IC95% 2, 22-1, 63; p = 0,000) and hyperfiltration (aOR 2, 19; 95%IC 2, 98 - 22, 25; p = 0,010). Conclusion The present study has shown that nearly fifty two out of one hundred SCD children bear a high platelet to lymphocyte ratio that is strongly and significantly associated with early markers of kidney disease.